Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PER2 | O15055 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6266813 | 0.86 | HTT (0.47) | HTTSMN1; SMN2GRM2BRD4HPGD | |
| SCHEMBL10906582 | 0.86 | HTT (0.47) | HTTSMN1; SMN2BRD4HPGDTSHR | |
| SCHEMBL10905416 | 0.85 | SMN1; SMN2 (0.63) | HTTALDH1A1POLBSMN1; SMN2BRD4 | |
| SCHEMBL9456545 | 0.85 | HTT (0.59) | HTTALDH1A1POLBSMN1; SMN2GRM2 | |
| SCHEMBL3240700 | 0.84 | HPGD (0.60) | HTTALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL9621552 | 0.81 | HTT (0.56) | HTTALDH1A1POLBSMN1; SMN2GRM2 | |
| SCHEMBL1268381 | 0.81 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2GRM2MMP1MMP13 | |
| SCHEMBL9621553 | 0.78 | HTT (0.62) | HTTALDH1A1POLBSMN1; SMN2GRM2 | |
| SCHEMBL7465720 | 0.78 | HTT (1.00) | HTTALDH1A1POLBSMN1; SMN2HPGD | |
| SCHEMBL27867003 | 0.77 | HPGD (0.52) | HTTALDH1A1POLBSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149808-A | Nootropics, antihypoxic agents | BOEHRINGER INGELHEIM KG (DE) | 1992-09-22 | — | — | US | disclosed |
| EP-0266563-B1 | USE OF 1-BENZYL-AMINO-ALKYL-PYRROLIDINONES AS ANTIDEPRESSANTS | BOEHRINGER INGELHEIM KG (DE) | 1992-01-29 | — | — | EP | disclosed |
| US-5073671-A | Nootropic and antihypoxic agents | BOEHRINGER INGELHEIM KG (DE) | 1991-12-17 | — | — | US | disclosed |
| US-4996224-A | 1-benzyl-4- or 5-pyrrolidinomethyl-pyrrolidin-2-ones and nootropic method of use thereof | BOEHRINGER INGELHEIM KG (DE) | 1991-02-26 | — | — | US | disclosed |
| US-4954516-A | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1990-09-04 | — | — | US | disclosed |
| US-4912129-A | Administering to humans | BOEHRINGER INGELHEIM GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| US-4833140-A | ANTIHYPOXIC AGENTS | BOEHRINGER INGELHEIM KG (DE) | 1989-05-23 | — | — | US | disclosed |
| EP-0136658-B1 | -1-BENZYL-AMINOALKYL-PYRROLIDINONES AND THEIR ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | BOEHRINGER INGELHEIM KG (DE) | 1989-04-26 | — | — | EP | disclosed |
| US-4812453-A | Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1989-03-14 | — | — | US | disclosed |
| EP-0132811-B1 | 1-SUBSTITUTED 4-HYDROXYMETHYL-PYRROLIDINONES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND INTERMEDIATE | BOEHRINGER INGELHEIM KG (DE) | 1988-09-28 | — | — | EP | disclosed |
| US-4767759-A | ANTIHYPOXICS | BOEHRINGER INGELHEIM KG (DE) | 1988-08-30 | — | — | US | disclosed |
| EP-0266563-A2 | Use of 1-benzyl-amino-alkyl-pyrrolidinones as antidepressants | BOEHRINGER INGELHEIM KG (DE) | 1988-05-11 | — | — | EP | disclosed |
| US-4581364-A | LEARNING ENHANCEMENT | BOEHRINGER INGELHEIM KG (DE) | 1986-04-08 | — | — | US | disclosed |
| EP-0136658-A2 | -1-Benzyl-aminoalkyl-pyrrolidinones and their addition salts, process for their preparation and pharmaceutical compounds containing them | BOEHRINGER INGELHEIM KG (DE) | 1985-04-10 | — | — | EP | disclosed |
| EP-0132811-A1 | 1-Substituted 4-hydroxymethyl-pyrrolidinones, processes for their preparation, pharmaceutical composition and intermediate | BOEHRINGER INGELHEIM KG (DE) | 1985-02-13 | — | — | EP | disclosed |