Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9622390 | 0.84 | HMGCR (0.38) | MAPTHTTHMGCRADRB2ADRB1 | |
| SCHEMBL9855396 | 0.83 | HMGCR (0.36) | HMGCRADRB2ADRB1ADRB3 | |
| SCHEMBL9855395 | 0.83 | HMGCR (0.36) | HMGCRADRB2ADRB1ADRB3 | |
| SCHEMBL9622023 | 0.83 | HMGCR (0.36) | HMGCRADRB2ADRB1ADRB3 | |
| SCHEMBL9622396 | 0.79 | HMGCR (0.46) | HMGCR | |
| SCHEMBL9420174 | 0.79 | HMGCR (0.48) | HMGCR | |
| SCHEMBL9422202 | 0.79 | HMGCR (0.48) | HMGCR | |
| SCHEMBL9527412 | 0.79 | HMGCR (0.48) | HMGCR | |
| SCHEMBL9420163 | 0.79 | HMGCR (0.48) | HMGCR | |
| SCHEMBL9622030 | 0.79 | HMGCR (0.48) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306649-B1 | 3,5-DIHYDROXYCARBOXYLIC ACIDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTIC PREPARATIONS AND INTERMEDIATE PRODUCTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-04 | — | — | EP | disclosed |
| EP-0306649-A1 | 3,5-Dihydroxycarboxylic acids and their derivatives, processes for their preparation, their use as medicaments, pharmaceutic preparations and intermediate products | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-03-15 | — | — | EP | disclosed |