Macrocarpal A

Macrocarpal A

SCHEMBL96222

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nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 11/20 1.00
PLA2R1 Q13018 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Macrocarpal A SCHEMBL13597681 1.00 PTPN1 (1.00) PTPN1PLA2R1
Macrocarpal A SCHEMBL27602003 1.00 PTPN1 (1.00) PTPN1PLA2R1
Macrocarpal A SCHEMBL4412279 1.00 PTPN1 (1.00) PTPN1PLA2R1
Macrocarpal A SCHEMBL96208 1.00 PTPN1 (1.00) PTPN1PLA2R1
Macrocarpal B SCHEMBL96058 1.00 PTPN1 (1.00) PTPN1PLA2R1
Macrocarpal A SCHEMBL23484425 1.00 PTPN1 (1.00) PTPN1PLA2R1
Macrocarpal A SCHEMBL13597677 1.00 PTPN1 (1.00) PTPN1PLA2R1
Macrocarpal A SCHEMBL4413981 1.00 PTPN1 (1.00) PTPN1PLA2R1
SCHEMBL12549605 0.91 PTPN1 (0.83) PTPN1PLA2R1
SCHEMBL12549608 0.91 PTPN1 (0.83) PTPN1PLA2R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120058172-A1 PLANT EXTRACTS FOR USE IN BRAIN MODULATION INTERMED DISCOVERY GMBH (DE) 2012-03-08 US disclosed
US-20120058172-A1 PLANT EXTRACTS FOR USE IN BRAIN MODULATION INTERMED DISCOVERY GMBH (DE) 2012-03-08 US disclosed
US-20110021613-A1 PLANTS EXTRACTS FOR USE IN BRAIN MODULATION INTERMED DISCOVERY GMBH (DE) 2011-01-27 US disclosed
US-20110021613-A1 PLANTS EXTRACTS FOR USE IN BRAIN MODULATION INTERMED DISCOVERY GMBH (DE) 2011-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021613-A1 PLANTS EXTRACTS FOR USE IN BRAIN MODULATION PYGB, FABP7, LANCL1 PTPN1 3670/4885PLA2R1 2001/4885
US-20120058172-A1 PLANT EXTRACTS FOR USE IN BRAIN MODULATION PYGB, FABP7, LANCL1 PTPN1 3808/4885PLA2R1 1998/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.