SCHEMBL9623751

SCHEMBL9623751

Cc1ccc2c(c1C)CCN(CCCN(C)CCc1cn(C)cn1)C2=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.35
HCN4 Q9Y3Q4 1/20 0.35
ALOX15 P16050 2/20 0.35
CYP3A4 P08684 1/20 0.35
KDM4E B2RXH2 1/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
RAB9A P51151 1/20 0.32
CNR2 P34972 1/20 0.32
CYP2C9 P11712 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
MTOR P42345 1/20 0.32
HRH4 Q9H3N8 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32
TERT O14746 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
DRD3 P35462 4/20 0.31
GRM5 P41594 1/20 0.31
SIGMAR1 Q99720 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9625336 0.83 CNR2 (0.46) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9624913 0.80 MAPT (0.35) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9624547 0.78 MAPT (0.36) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9624463 0.78 MAPT (0.36) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9624345 0.78 MAPT (0.36) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9624741 0.78 MAPT (0.39) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9624078 0.78 MAPT (0.39) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9625024 0.78 MAPT (0.36) MAPTHCN4ALOX15CYP3A4KDM4E
SCHEMBL9624297 0.78 ALDH1A1 (0.37) ALOX15KDM4ENPC1ALDH1A1RAB9A
SCHEMBL9624905 0.78 MAPT (0.36) MAPTHCN4ALOX15CYP3A4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5116986-A HETEROAROMATIC AMINE DERIVATIVES DR. KARL THOMAE GMBH (DE) 1992-05-26 US disclosed
US-4912115-A Cardiovascular disorders DR. KARL THOMAE GMBH (DE) 1990-03-27 US disclosed
EP-0269968-A2 Heteroaromatic amine derivatives, medicaments containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1988-06-08 EP disclosed