SCHEMBL9623993

SCHEMBL9623993

C[Si](C)(C)CN1CCOC1=O

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 2/20 0.44
KDM4E B2RXH2 2/20 0.41
NAAA Q02083 2/20 0.36
PER2 O15055 1/20 0.34
CRY2 Q49AN0 1/20 0.34
GRM2 Q14416 1/20 0.34
NQO2 P16083 1/20 0.34
LTA4H P09960 1/20 0.32
CNR1 P21554 1/20 0.32
CNR2 P34972 1/20 0.32
GRIN1 Q05586 1/20 0.32
GRIN2B Q13224 1/20 0.32
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9624340 0.79 KDM4E (0.46) PIK3CDKDM4ENAAAPER2CRY2
SCHEMBL261199 0.77
SCHEMBL8593693 0.75
SCHEMBL2781821 0.74
SCHEMBL11062023 0.74 PIK3CD (0.46) PIK3CDKDM4ENAAAPER2CRY2
SCHEMBL509994 0.73
SCHEMBL3293772 0.73
SCHEMBL3295411 0.73
SCHEMBL12413745 0.72 PIK3CD (0.79) PIK3CDKDM4ENAAAPER2CRY2
SCHEMBL5807789 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5130310-A Hypotensive agents or antispasm drugs HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-14 US disclosed
EP-0379953-A2 Substituted benzo[b]pyrans, process for their preparation, their use and pharmaceutical preparations based on these compounds HOECHST AKTIENGESELLSCHAFT (DE) 1990-08-01 EP disclosed