Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 8/20 | 0.48 |
| ▸ | DRD4 | P21917 | 6/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL333182 | 0.85 | HCN4 (0.58) | MEN1KMT2AABCB1DRD3DRD4 | |
| SCHEMBL9666604 | 0.84 | MEN1 (0.61) | MEN1KMT2AABCB1DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL10597759 | 0.84 | CYP3A4 (0.59) | MEN1KMT2AABCB1DRD3DRD4 | |
| SCHEMBL380658 | 0.82 | DRD3 (0.52) | DRD3DRD4DRD2DRD1 | |
| SCHEMBL11532852 | 0.81 | MAPT (0.55) | MEN1KMT2AABCB1DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL11536298 | 0.80 | CYP3A4 (0.56) | MEN1KMT2AABCB1DRD3DRD4 | |
| SCHEMBL31134729 | 0.80 | MEN1 (0.56) | MEN1KMT2AABCB1DRD3DRD4 | |
| SCHEMBL9665585 | 0.79 | MEN1 (0.61) | MEN1KMT2AABCB1DRD3DRD4 | |
| SCHEMBL9625180 | 0.77 | MEN1 (0.58) | MEN1KMT2AABCB1DRD3DRD4 | |
| SCHEMBL9667936 | 0.77 | MEN1 (0.55) | MEN1KMT2AABCB1DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259793-B1 | NAPHTHYL DERIVATIVES, MEDICAMENTS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| US-4871735-A | HYPOTENSIVE, ANTIISCHEMIC AGENTS | DR. KARL THOMAE GMBH | 1989-10-03 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |
| EP-0259793-A1 | Naphthyl derivatives, medicaments containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |