Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PGK1 | P00558 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10597759 | 0.99 | CYP3A4 (0.59) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL14696925 | 0.89 | GAA (0.68) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL10978574 | 0.88 | HCN4 (0.56) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL15980993 | 0.85 | GAA (0.62) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL9624879 | 0.85 | MEN1 (0.58) | HCN4MAPTHTR1ADRD3DRD1 | |
| SCHEMBL9032662 | 0.84 | GAA (0.61) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL14696959 | 0.84 | GAA (0.61) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL30081993 | 0.84 | GAA (0.61) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL11094479 | 0.83 | HCN4 (0.55) | HCN4MAPTGAASMN1; SMN2SLC6A4 | |
| SCHEMBL9032571 | 0.83 | HCN4 (0.60) | HCN4MAPTGAASMN1; SMN2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113030328-B | Method for detecting genotoxic impurities in ivabradine hydrochloride | 北京阳光诺和药物研究股份有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-113030328-A | Method for detecting genotoxic impurities in ivabradine hydrochloride | 北京阳光诺和药物研究股份有限公司 | 2021-06-25 | — | — | CN | disclosed |
| EP-2566850-B1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF IVABRADINE HYDROBROMIDE SALT | RICHTER GEDEON NYRT (HU) | 2018-04-11 | — | — | EP | disclosed |
| EP-2726462-B1 | ACETONE SOLVATE OF IVABRADINE HYDROCHLORIDE | SANDOZ AG (CH) | 2017-03-22 | — | — | EP | disclosed |
| US-8415468-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2013-04-09 | — | — | US | disclosed |
| EP-2202225-B1 | New method for synthesising ivabradine and its added salts with a pharmaceutically acceptable acid. | SERVIER LAB (FR) | 2012-10-24 | — | — | EP | disclosed |
| US-8119794-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2012-02-21 | — | — | US | disclosed |
| US-8119794-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2012-02-21 | — | — | US | disclosed |
| US-8097720-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | Les Laboratories Server (FR) | 2012-01-17 | — | — | US | disclosed |
| EP-2398802-A1 | DERIVATIVES OF 6-CYCLOAMINO-2-THIENYL-3-(PYRIDIN-4-YL)IMIDAZO[1,2-b]-PYRIDAZINE AND 6-CYCLOAMINO-2-FURANYL-3-(PYRIDIN-4-YL)IMIDAZO[1,2-b]-PYRIDAZINE, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI (FR) | 2011-12-28 | — | — | EP | disclosed |
| EP-0109636-B1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1989-01-18 | — | — | EP | disclosed |
| US-4737495-A | ANTIALLERGENS, ANTISCHEMIC, HYPOTENSIVE AGENTS | DR. KARL TOMAE, GMBH (DE) | 1988-04-12 | — | — | US | disclosed |
| EP-0259793-A1 | Naphthyl derivatives, medicaments containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0204349-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-12-10 | — | — | EP | disclosed |
| US-4604389-A | Benzazepine derivatives | DR. KARL THOMAE GMBH (DE) | 1986-08-05 | — | — | US | disclosed |
| EP-0161599-A2 | Benzazepine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |
| EP-0065229-B1 | BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS | Dr. Karl Thomae GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |
| US-4490369-A | HYPOTENSIVE, BRRADYCARDIAL | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-25 | — | — | US | disclosed |
| EP-0109636-A2 | Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds | Dr. Karl Thomae GmbH (DE) | 1984-05-30 | — | — | EP | disclosed |
| EP-0065229-A1 | Benzazepines, process for their preparation and their application as pharmaceutical preparations | Dr. Karl Thomae GmbH (DE) | 1982-11-24 | — | — | EP | disclosed |