Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | BRD4 | O60885 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | TOP2A | P11388 | 1/20 | 0.65 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10745959 | 0.88 | ALDH1A1 (0.67) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL22372463 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9008319 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL10748665 | 0.87 | ALDH1A1 (0.53) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9626236 | 0.87 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL5083273 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL11392814 | 0.84 | ALDH1A1 (0.74) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL30605634 | 0.84 | ALDH1A1 (0.74) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL11026221 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL13916906 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4705788-A | Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | claimed |
| EP-0198192-B1 | 7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4 -DIHYDRO-4-OXO-QUINOLINE CARBOXYLIC ACIDS, METHOD FOR THEIR PREPARATION, AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0300155-A2 | Cyclopropyl amines | BAYER AG (DE) | 1989-01-25 | — | — | EP | disclosed |
| US-4705788-A | Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |
| EP-0198192-A1 | 7-Amino-1-(subst.cyclopropyl)-1,4 -dihydro-4-oxo-quinoline carboxylic acids, method for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-10-22 | — | — | EP | disclosed |