Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.47 |
| ▸ | TOP2A | P11388 | 5/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626416 | 0.90 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL10862601 | 0.90 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL8433503 | 0.88 | TOP2A (0.58) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL9626257 | 0.88 | ALDH1A1 (0.35) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL9626565 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL9627119 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL9626958 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL10366548 | 0.79 | KDM4E (0.70) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL10860972 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL10860981 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198192-B1 | 7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4 -DIHYDRO-4-OXO-QUINOLINE CARBOXYLIC ACIDS, METHOD FOR THEIR PREPARATION, AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1992-05-13 | — | — | EP | claimed |
| US-4705788-A | Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | claimed |
| EP-0198192-A1 | 7-Amino-1-(subst.cyclopropyl)-1,4 -dihydro-4-oxo-quinoline carboxylic acids, method for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-10-22 | — | — | EP | claimed |
| EP-0198192-B1 | 7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4 -DIHYDRO-4-OXO-QUINOLINE CARBOXYLIC ACIDS, METHOD FOR THEIR PREPARATION, AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0300155-A2 | Cyclopropyl amines | BAYER AG (DE) | 1989-01-25 | — | — | EP | disclosed |
| US-4705788-A | Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |
| EP-0198192-A1 | 7-Amino-1-(subst.cyclopropyl)-1,4 -dihydro-4-oxo-quinoline carboxylic acids, method for their preparation, and antibacterial agents containing them | BAYER AG (DE) | 1986-10-22 | — | — | EP | disclosed |