Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 9/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9462437 | 1.00 | CASR (0.38) | CASRCYP2D6ADRB2SLC6A2SLC6A4 | |
| SCHEMBL9462848 | 0.90 | SLC2A1 (0.46) | CASRADRB2SLC6A4KCNH2SLC2A1 | |
| SCHEMBL9462359 | 0.90 | SLC2A1 (0.46) | CASRADRB2SLC6A4KCNH2SLC2A1 | |
| SCHEMBL9463196 | 0.89 | SLC2A1 (0.41) | CASRADRB2SLC6A4KCNH2SLC2A1 | |
| SCHEMBL9463189 | 0.89 | SLC2A1 (0.41) | CASRADRB2SLC6A4KCNH2SLC2A1 | |
| SCHEMBL10568580 | 0.87 | KDM4E (0.43) | CASRCYP2D6ADRB2SLC6A2SLC6A4 | |
| SCHEMBL9462681 | 0.87 | SLC2A1 (0.38) | CASRADRB2SLC6A4KCNH2SLC2A1 | |
| SCHEMBL9462679 | 0.87 | SLC2A1 (0.38) | CASRADRB2SLC6A4KCNH2SLC2A1 | |
| SCHEMBL9462487 | 0.87 | SLC2A1 (0.41) | CASRCYP2D6ADRB2SLC6A2SLC6A4 | |
| SCHEMBL9462326 | 0.87 | CASR (0.52) | CASRCYP2D6ADRB2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130314-A | Hypotensive agents | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1992-07-14 | — | — | US | disclosed |
| US-5082844-A | Hypotensive | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| EP-0404050-A1 | Pyridazinone derivatives | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1990-12-27 | — | — | EP | disclosed |