Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 3/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627737 | 0.91 | HTT (0.52) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9627451 | 0.91 | HTT (0.56) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL7918996 | 0.87 | HTT (0.75) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9628372 | 0.87 | MAPT (0.61) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9628422 | 0.86 | HTT (0.53) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9627465 | 0.83 | HTT (0.69) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9657650 | 0.82 | HTT (0.42) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9656682 | 0.81 | ALDH1A1 (0.49) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9627519 | 0.81 | HTT (0.58) | HTTKDM4EMAPTHSD17B10GAA | |
| SCHEMBL9627634 | 0.79 | HTT (0.63) | HTTKDM4EMAPTHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |