Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628088 | 0.86 | MAOB (0.44) | ABCB11MAOBAMY1AERN1MEN1 | |
| SCHEMBL9627379 | 0.85 | ABCB11 (0.68) | ABCB11TNFSF11AMY1ATSHRLMNA | |
| SCHEMBL9629306 | 0.85 | ABCB11 (0.68) | ABCB11TNFSF11AMY1ATSHRLMNA | |
| SCHEMBL9627602 | 0.85 | ABCB11 (0.46) | ABCB11TSHRLMNASMN1; SMN2MEN1 | |
| SCHEMBL9627715 | 0.84 | TNFSF11 (0.46) | TNFSF11MAOBTSHRLMNASMN1; SMN2 | |
| SCHEMBL9627905 | 0.82 | TNFSF11 (0.45) | TNFSF11AMY1ATSHRERN1LMNA | |
| SCHEMBL9627969 | 0.82 | TNFSF11 (0.45) | TNFSF11TSHRERN1LMNASMN1; SMN2 | |
| SCHEMBL9627417 | 0.82 | ABCB11 (0.68) | ABCB11TNFSF11AMY1ATSHRLMNA | |
| SCHEMBL9629380 | 0.81 | HTT (0.55) | TNFSF11TSHRLMNAMEN1KMT2A | |
| SCHEMBL9628189 | 0.81 | ABCB11 (0.70) | ABCB11TNFSF11AMY1ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |