Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAOA | P21397 | 3/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | CDC25B | P30305 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | ATM | Q13315 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.61 |
| ▸ | IDO1 | P14902 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | CDC25A | P30304 | 2/20 | 0.61 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16656176 | 0.88 | MAPT (0.53) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| SCHEMBL21887173 | 0.81 | BACE1 (0.70) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| SCHEMBL16656178 | 0.81 | MAPT (0.53) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| SCHEMBL16656175 | 0.80 | MAOB (0.45) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| SCHEMBL9628450 | 0.79 | MEN1 (0.58) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| SCHEMBL3133429 | 0.79 | IDO1 (0.65) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| Menadione SCHEMBL25970 | 0.77 | MAPT (1.00) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| Menadione SCHEMBL1364028 | 0.77 | MAPT (1.00) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| Menadione SCHEMBL19356853 | 0.77 | MAPT (1.00) | MAPTMEN1BLMKMT2ASMN1; SMN2 | |
| Menadione SCHEMBL29351164 | 0.77 | MAPT (1.00) | MAPTMEN1BLMKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |