Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.55 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.54 |
| ▸ | CDC25B | P30305 | 5/20 | 0.47 |
| ▸ | CDC25A | P30304 | 4/20 | 0.47 |
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPRF | P10586 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30038980 | 0.79 | PTPN1 (0.70) | HIF1AEPAS1PTPN1CDC25BCDC25A | |
| SCHEMBL9627646 | 0.79 | PTPN1 (0.70) | HIF1AEPAS1PTPN1CDC25BCDC25A | |
| SCHEMBL9628563 | 0.75 | BACE1 (0.49) | PTPN1CDC25BCDC25ABACE1PTPRC | |
| SCHEMBL9627964 | 0.74 | CDC25A (0.62) | HIF1APTPN1CDC25BCDC25ABACE1 | |
| SCHEMBL16491897 | 0.73 | MEN1 (0.55) | PTPN1CDC25BBACE1PTPRCPTPRF | |
| SCHEMBL1038974 | 0.73 | ADORA2A (0.57) | CDC25BPTPRCMAPK1MEN1KMT2A | |
| SCHEMBL11424452 | 0.72 | HDAC4 (0.52) | CDC25BBACE1PTPRCMAPK1MEN1 | |
| SCHEMBL22187708 | 0.72 | MEN1 (0.52) | PTPN1CDC25BBACE1PTPRCPTPRF | |
| Ammonia Solution, Strong SCHEMBL27523091 | 0.71 | ADORA2A (0.55) | CDC25BPTPRCMAPK1MEN1KMT2A | |
| SCHEMBL17969793 | 0.71 | CDC25B (0.60) | HIF1AEPAS1PTPN1CDC25BCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |