Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | CDC25C | P30307 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157762 | 0.96 | KCNH2 (0.71) | KCNH2TSHRSIGMAR1ATML3MBTL1 | |
| SCHEMBL6778459 | 0.86 | KCNH2 (0.76) | KCNH2TSHRATML3MBTL1KCNJ1 | |
| SCHEMBL17539702 | 0.86 | CYP1A2 (0.62) | KCNH2 | |
| SCHEMBL11244131 | 0.85 | KCNH2 (0.84) | KCNH2TSHRKCNJ1 | |
| SCHEMBL5632454 | 0.85 | KCNH2 (0.83) | KCNH2TSHRATML3MBTL1KCNJ1 | |
| SCHEMBL3156935 | 0.83 | KCNH2 (0.57) | KCNH2TSHRSIGMAR1CDC25CHRH3 | |
| SCHEMBL6369107 | 0.83 | KCNH2 (1.00) | KCNH2TSHR | |
| SCHEMBL11223279 | 0.83 | KCNH2 (1.00) | KCNH2TSHR | |
| SCHEMBL11230222 | 0.83 | KCNH2 (1.00) | KCNH2TSHR | |
| SCHEMBL8780932 | 0.83 | KCNH2 (0.56) | KCNH2TSHRSIGMAR1KCNJ1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |