Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CDC25C | P30307 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157762 | 0.83 | KCNH2 (0.71) | KCNH2SIGMAR1TSHRCDC25CKCNJ1 | |
| SCHEMBL9628232 | 0.83 | KCNH2 (0.76) | KCNH2SIGMAR1TSHRCDC25CKCNJ1 | |
| SCHEMBL777298 | 0.82 | KCNH2 (0.60) | KCNH2SIGMAR1TSHRCDC25CCRHBP | |
| SCHEMBL9628028 | 0.82 | KCNH2 (0.74) | KCNH2SIGMAR1TSHRCDC25CCRHBP | |
| SCHEMBL3143117 | 0.78 | KCNH2 (0.64) | KCNH2SIGMAR1TSHRCDC25CCRHBP | |
| SCHEMBL13897015 | 0.77 | KCNH2 (0.72) | KCNH2SIGMAR1TSHRCDC25CMAPT | |
| Dimethylamine SCHEMBL5708300 | 0.77 | KCNH2 (0.55) | KCNH2SIGMAR1TSHRCDC25CCRHBP | |
| SCHEMBL6778459 | 0.77 | KCNH2 (0.76) | KCNH2TSHRMAPTCRHBPCRHR2 | |
| SCHEMBL670267 | 0.76 | TSHR (0.64) | KCNH2TSHRMAPTKCNJ1LOXL2 | |
| SCHEMBL11132823 | 0.76 | KCNH2 (0.57) | KCNH2SIGMAR1TSHRCDC25CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |