Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 17/20 | 0.44 |
| ▸ | MPEG1 | Q2M385 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11661829 | 1.00 | PTPN1 (0.50) | PTPN1ALOX5MPEG1ALDH1A1MAPT | |
| SCHEMBL9627408 | 0.87 | MAPT (0.42) | PTPN1ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL9628375 | 0.84 | ALOX5 (0.57) | PTPN1ALOX5MPEG1ALDH1A1MAPT | |
| SCHEMBL11660838 | 0.84 | ALOX5 (0.57) | PTPN1ALOX5MPEG1ALDH1A1MAPT | |
| SCHEMBL10951203 | 0.84 | ALOX5 (0.57) | PTPN1ALOX5MPEG1ALDH1A1MAPT | |
| SCHEMBL11658545 | 0.83 | PTPN1 (0.51) | PTPN1ALOX5MPEG1 | |
| SCHEMBL9628157 | 0.83 | ALOX5 (0.55) | PTPN1ALOX5MPEG1ALDH1A1MAPT | |
| SCHEMBL9629370 | 0.82 | PTPN1 (0.50) | PTPN1ALOX5MPEG1ALDH1A1MAPT | |
| SCHEMBL10339035 | 0.81 | PTPN1 (0.49) | PTPN1ALOX5MPEG1ALDH1A1MAPT | |
| SCHEMBL9627522 | 0.80 | MAPT (0.45) | ALDH1A1MAPTTHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |