Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10458812 | 0.98 | TDP1 (0.40) | HRH2HRH1HRH4HRH3TDP1 | |
| Hydrochloric Acid SCHEMBL10458810 | 0.98 | TDP1 (0.40) | HRH2HRH1HRH4HRH3TDP1 | |
| Bromide SCHEMBL11679779 | 0.98 | HRH2 (0.37) | HRH2HRH1HRH4HRH3TDP1 | |
| Bromide SCHEMBL11752048 | 0.88 | HRH2 (0.35) | HRH2HRH1HRH4HRH3TDP1 | |
| SCHEMBL11221693 | 0.82 | — | — | |
| SCHEMBL11353887 | 0.79 | HRH2 (0.31) | HRH2HRH1HRH4HRH3TDP1 | |
| SCHEMBL11260172 | 0.78 | — | — | |
| SCHEMBL11534184 | 0.77 | HRH4 (0.33) | HRH2HRH1HRH4HRH3 | |
| SCHEMBL11228692 | 0.75 | HRH2 (0.46) | HRH2HRH1HRH4HRH3TDP1 | |
| SCHEMBL10568885 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916233-A | Method for production of 4-methyl-5-(2-aminoethyl)-thiomethyl)-imidazole | NIPPON SHOKUBAI KAGAKU KOGYO CO., LTD. (JP) | 1990-04-10 | — | — | US | claimed |
| EP-0339970-A2 | Method for production of 4-methyl-5-((2-aminoethyl)-thiomethyl)-imidazole | NIPPON SHOKUBAI CO., LTD. (JP) | 1989-11-02 | — | — | EP | claimed |
| US-4347373-A | Derivatives of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole | TURCONI FRANCO | 1982-08-31 | — | — | US | claimed |
| EP-0036684-A1 | Derivatives of 4-methyl-5-(2-aminoethyl)-thiomethyl-imidazole having therapeutic activity | Turconi, Franco (IT) | 1981-09-30 | — | — | EP | claimed |
| EP-0004535-B1 | PROCESS FOR PREPARING 4-METHYL-5-((2-AMINOETHYL)-THIOMETHYL)-IMIDAZOLE-DIHYDRO CHLORIDE | BASF Aktiengesellschaft (DE) | 1981-04-29 | — | — | EP | claimed |
| EP-0006102-B1 | 1-HYDROXYMETHYLIMIDAZOLES, THEIR PREPARATION AND USE AS CHEMICAL INTERMEDIATES | BASF Aktiengesellschaft (DE) | 1981-02-11 | — | — | EP | claimed |
| JP-2268166-A | — | — | None | — | — | JP | disclosed |
| JP-2076859-A | — | — | None | — | — | JP | disclosed |
| JP-57014576-A | — | — | None | — | — | JP | disclosed |
| JP-2076858-A | — | — | None | — | — | JP | disclosed |
| JP-2049773-A | — | — | None | — | — | JP | disclosed |
| JP-2049773-A | — | — | None | — | — | JP | disclosed |
| JP-2076858-A | — | — | None | — | — | JP | disclosed |
| US-4129657-A | Imidazole guanidines and use as inhibitors of histamine activity | SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-12-12 | — | — | US | disclosed |
| US-4118496-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-10-03 | — | — | US | disclosed |
| US-4109003-A | N-(IMIDAZOLYL-METHYLTHIO-ALKYL) DERIVATIVES OF S-ALKYL ISOTHIOUREAS; ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-22 | — | — | US | disclosed |
| US-4107319-A | GUANIDINES, BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-15 | — | — | US | disclosed |
| US-4104382-A | (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | disclosed |
| US-4063023-A | Process for preparing 4-(hydroxymethyl)imidazole compounds | SK&F LAB CO. (US) | 1977-12-13 | — | — | US | disclosed |
| US-4000302-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-12-28 | — | — | US | disclosed |