SCHEMBL9628628

SCHEMBL9628628

Cc1cc([Si](C)(C)C)c([Si](C)(C)C)cc1C

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.33
NQO2 P16083 1/20 0.33
CYP3A4 P08684 1/20 0.33
MAPK1 P28482 1/20 0.33
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
IDO1 P14902 1/20 0.33
FABP6 P51161 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9742211 0.87 CYP3A4 (0.36) TSHRNQO2CYP3A4MAPK1NOS3
SCHEMBL12818051 0.86
SCHEMBL6425318 0.86 IDO1 (0.33) IDO1
SCHEMBL4572706 0.81 IDO1 (0.32) IDO1
SCHEMBL27946342 0.80
SCHEMBL12817359 0.78
SCHEMBL12817330 0.76
SCHEMBL12816949 0.76
SCHEMBL4586058 0.74 IDO1 (0.30) IDO1
SCHEMBL12818366 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016100754-A1 QUANTITATIVE INTRAMOLECULAR FISSION IN OLIGOACENES, MATERIALS, AND METHODS OF USE THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2016-06-23 WO disclosed
EP-0236261-B1 POLYMERS CONTAINING ORGANOMETALLIC DERIVATIVES CIBA-GEIGY AG (CH) 1992-04-08 EP disclosed
US-4820829-A POLYMERIZABLE FOR USE AS PHOTORESISTS CIBA-GEIGY CORPORATION (US) 1989-04-11 US disclosed
EP-0229745-B1 SUBSTITUTED O-PHTHALALDEHYDES CIBA-GEIGY AG (CH) 1989-03-01 EP disclosed
US-4734481-A POLYPHTHALDEHYDES; PHOTORESISTS CIBA-GEIGY CORPORATION (US) 1988-03-29 US disclosed
EP-0236261-A2 Polymers containing organometallic derivatives CIBA-GEIGY AG (CH) 1987-09-09 EP disclosed
EP-0229745-A2 Substituted o-phthalaldehydes CIBA-GEIGY AG (CH) 1987-07-22 EP disclosed