SCHEMBL9628907

SCHEMBL9628907

c1ccc2c(N=C(Nc3cccc4ccccc34)Nc3cccc4ccccc34)cccc2c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.71
GRIN2D O15399 1/20 0.71
GRIN3B O60391 1/20 0.71
GRIN1 Q05586 1/20 0.71
GRIN2A Q12879 1/20 0.71
GRIN2B Q13224 1/20 0.71
GRIN2C Q14957 1/20 0.71
GRIN3A Q8TCU5 1/20 0.71
KDM4E B2RXH2 2/20 0.53
GAA P10253 1/20 0.53
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
CYP1A2 P05177 2/20 0.53
CYP3A4 P08684 2/20 0.53
CYP2D6 P10635 2/20 0.53
CYP2C9 P11712 2/20 0.53
CYP2C19 P33261 2/20 0.53
CXCR4 P61073 2/20 0.49
ALDH1A1 P00352 1/20 0.47
HPGD P15428 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3076830 0.86 SIGMAR1 (0.58) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL10577877 0.86 SIGMAR1 (0.58) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL3082630 0.85 SIGMAR1 (0.57) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL3071610 0.83 SIGMAR1 (0.63) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL3071612 0.83 SIGMAR1 (0.63) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL1273875 0.83 SIGMAR1 (1.00) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL3085284 0.83 SIGMAR1 (0.67) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL3085282 0.83 SIGMAR1 (0.67) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL2740846 0.82 SIGMAR1 (0.56) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
Hydrochloric Acid SCHEMBL9438295 0.81 SIGMAR1 (0.97) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0178952-B1 TONER, CHARGE-IMPARTING MATERIAL AND COMPOSITION CONTAINING POSITIVELY CHARGEABLE COMPOUND CANON KABUSHIKI KAISHA (JP) 1992-04-01 EP disclosed
US-5071727-A Development of electrostatic latent images CANON KABUSHIKI KAISHA (JP) 1991-12-10 US disclosed
EP-0178952-A2 Toner, charge-imparting material and composition containing positively chargeable compound CANON KABUSHIKI KAISHA (JP) 1986-04-23 EP disclosed