Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | SSTR5 | P35346 | 8/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.58 |
| ▸ | EED | O75530 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | HLA-A | P04439 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995354 | 0.96 | LMNA (0.71) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9629448 | 0.93 | LMNA (0.57) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9698303 | 0.92 | LMNA (0.65) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9630113 | 0.91 | LMNA (0.67) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| Hydrochloric Acid SCHEMBL9699489 | 0.90 | LMNA (0.64) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9632037 | 0.90 | GAA (0.55) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9629387 | 0.89 | GAA (0.54) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9630599 | 0.89 | GAA (0.53) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9630400 | 0.88 | GAA (0.53) | LMNAGAAALDH1A1SSTR5KCNH2 | |
| SCHEMBL9630423 | 0.88 | LMNA (0.63) | LMNAGAAALDH1A1SSTR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |