Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HLA-A | P04439 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631303 | 0.91 | ROCK2 (0.35) | TP53HTR1AROCK2CCR2ROCK1 | |
| SCHEMBL9630310 | 0.86 | EED (0.40) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL9630327 | 0.85 | EED (0.56) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL9688923 | 0.85 | EED (0.46) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL9629390 | 0.85 | EED (0.38) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL1151619 | 0.81 | SSTR5 (0.59) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL9629505 | 0.81 | SSTR5 (0.47) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL1152716 | 0.81 | KCNH2 (0.41) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL9303034 | 0.80 | KCNH2 (0.40) | EEDKCNH2NR4A2SSTR5OPRK1 | |
| SCHEMBL9630454 | 0.79 | EED (0.50) | EEDKCNH2NR4A2SSTR5OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |