Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629376 | 0.94 | KCNH2 (0.57) | KCNH2NR4A2TSHRSMN1; SMN2KDM4E | |
| SCHEMBL9698816 | 0.88 | KCNH2 (0.65) | KCNH2NR4A2TSHRSMN1; SMN2KDM4E | |
| Oxalic Acid SCHEMBL9630409 | 0.82 | SSTR5 (0.45) | KCNH2NR4A2TSHRSMN1; SMN2KDM4E | |
| Oxalic Acid SCHEMBL9630418 | 0.82 | SSTR5 (0.45) | KCNH2NR4A2TSHRSMN1; SMN2KDM4E | |
| SCHEMBL9631535 | 0.80 | MAPT (0.42) | KCNH2NR4A2MAPTHPGDMAOB | |
| Hydrochloric Acid SCHEMBL9631314 | 0.79 | MAPT (0.42) | KCNH2NR4A2MAPTHPGDMAOB | |
| SCHEMBL7860383 | 0.78 | KCNH2 (0.48) | KCNH2NR4A2TSHRSMN1; SMN2KDM4E | |
| SCHEMBL7860380 | 0.78 | KCNH2 (0.48) | KCNH2NR4A2TSHRSMN1; SMN2KDM4E | |
| SCHEMBL9698262 | 0.76 | SMN1; SMN2 (0.54) | TSHRSMN1; SMN2KDM4EMAPTHPGD | |
| SCHEMBL9630499 | 0.75 | SMN1; SMN2 (0.51) | TSHRSMN1; SMN2KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |
| EP-0297661-A1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-04 | — | — | EP | disclosed |