⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240667 | 0.94 | — | — | |
| SCHEMBL441909 | 0.92 | CYP1A2 (0.42) | — | |
| SCHEMBL542372 | 0.88 | — | — | |
| SCHEMBL6593058 | 0.84 | — | — | |
| SCHEMBL6033221 | 0.79 | CYP1A2 (0.46) | — | |
| SCHEMBL450392 | 0.77 | CYP1A2 (0.50) | — | |
| SCHEMBL6589344 | 0.77 | CYP1A2 (0.50) | — | |
| SCHEMBL7403531 | 0.75 | SIGMAR1 (0.50) | — | |
| SCHEMBL452274 | 0.75 | SIGMAR1 (0.50) | — | |
| SCHEMBL868345 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308510-B1 | Agent for regeneration and/or protection of nerves | ONO PHARMACEUTICAL CO (JP) | 2016-03-16 | — | — | EP | disclosed |
| US-8673889-B2 | BLT2-mediated disease, BLT2 binding agent and the compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-03-18 | — | — | US | disclosed |
| US-8501793-B2 | Blood flow promoters for cauda equina tissues | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-08-06 | — | — | US | disclosed |
| US-20130143934-A1 | AGENT FOR REGENERATION AND/OR PROTECTION OF NERVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-06-06 | — | — | US | disclosed |
| US-8404858-B2 | Agent for regeneration and/or protection of nerves | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-03-26 | — | — | US | disclosed |
| EP-2494990-A1 | Agent for regeneration and/or protection of nerves | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-09-05 | — | — | EP | disclosed |
| EP-2308510-A1 | Agent for regeneration and/or protection of nerves | Ono Pharmaceutical Co., Ltd. (JP) | 2011-04-13 | — | — | EP | disclosed |
| US-20110059920-A1 | AGENT FOR REGENERATION AND/OR PROTECTION OF NERVES | ONO PHARMACEUTICAL CO., LTD (JP) | 2011-03-10 | — | — | US | disclosed |
| US-20110015238-A1 | BLOOD FLOW PROMOTERS FOR CAUDA EQUINA TISSUES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| US-7863263-B2 | Agent for regeneration and/or protection of nerves | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-04 | — | — | US | disclosed |
| US-20050032182-A1 | Process for the enantioselective preparation of secondary alcohols by lipase-catalyzed solvolysis of the corresponding acetoacetic esters | CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH | 2005-02-10 | — | — | US | disclosed |
| EP-1505156-A1 | Process for the enantioselective preparation of secondary alcohols by lipase catalysed solvolysis of the corresponding acetoacetic acid ester | Consortium für elektrochemische Industrie GmbH (DE) | 2005-02-09 | — | — | EP | disclosed |
| EP-0823423-B1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-6140338-A | FOR TREATING ACUTE INFLAMMATORY DISEASES, CHRONIC INFLAMMATORY DISEASES, ACQUIRED IMMUNE DEFICIENCY SYNDROME, CANCER, ISCHEMIC REFLOW DISORDER AND/OR ARTERIOSCLEROSIS | BANYU PHARMACEUTICAL, CO., LTD. (JP) | 2000-10-31 | — | — | US | disclosed |
| US-6040449-A | USEFUL FOR FORMING FLUORINE CONTAINING 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES, USEFUL AS ANTAGONIST FOR MUSCARINIC M3 RECEPTORS AND LESS SIDE EFFECT | BANYU PHARMACEUTICAL CO LTD (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5948792-A | POTENT AND SELECTIVE ANTAGONISTS FOR MUSCARINIC M.SUB.3 RECEPTORS WITH LITTLE SIDE EFFECTS. | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0930298-A1 | FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-07-21 | — | — | EP | disclosed |
| EP-0916668-A1 | CHEMOKINE RECEPTOR ANTAGONISTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-05-19 | — | — | EP | disclosed |
| US-5750540-A | SIDE EFFECT REDUCTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0823423-A1 | 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |