Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.46 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560605 | 0.95 | KCNH2 (0.61) | KCNH2KCNN3HDAC6KCNN1KCNN2 | |
| Water SCHEMBL8562628 | 0.95 | KCNH2 (0.61) | KCNH2KCNN3HDAC6KCNN1KCNN2 | |
| Water SCHEMBL8566156 | 0.95 | KCNH2 (0.61) | KCNH2KCNN3HDAC6KCNN1KCNN2 | |
| Hydrochloric Acid SCHEMBL8564807 | 0.93 | KCNH2 (0.60) | KCNH2KCNN3HDAC6KCNN1KCNN2 | |
| Isopropyl Alcohol SCHEMBL8628484 | 0.89 | KCNH2 (0.56) | KCNH2KCNN3HDAC6NPC1RAB9A | |
| SCHEMBL27898220 | 0.85 | RIPK1 (0.62) | KCNN3HDAC6NPC1RAB9ARIPK1 | |
| Cyclamic Acid SCHEMBL8564519 | 0.85 | NPC1 (0.50) | KCNH2KCNN3HDAC6NPC1RAB9A | |
| SCHEMBL9690333 | 0.84 | PIM1 (0.50) | KCNH2PIM1RIPK1 | |
| SCHEMBL14155576 | 0.83 | RIPK1 (0.65) | KCNN3HDAC6NPC1RAB9ARIPK1 | |
| SCHEMBL28406604 | 0.82 | HDAC6 (0.57) | KCNH2KCNN3HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |