Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.55 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.55 |
| ▸ | SSTR5 | P35346 | 7/20 | 0.62 |
| ▸ | EED | O75530 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MLNR | O43193 | 1/20 | 0.55 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | HLA-A | P04439 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9630385 | 1.00 | SSTR5 (0.62) | SSTR5EEDKCNH2NR4A2HRH1 | |
| SCHEMBL10428783 | 0.92 | SSTR5 (0.70) | SSTR5EEDKCNH2NR4A2HRH1 | |
| Water SCHEMBL1152158 | 0.82 | SSTR5 (0.55) | SSTR5EEDKCNH2NR4A2HRH1 | |
| Oxalic Acid SCHEMBL9629805 | 0.82 | SSTR5 (0.67) | SSTR5EEDKCNH2NR4A2HRH1 | |
| Oxalic Acid SCHEMBL9629799 | 0.82 | SSTR5 (0.67) | SSTR5EEDKCNH2NR4A2HRH1 | |
| Oxalic Acid SCHEMBL9629813 | 0.82 | SSTR5 (0.67) | SSTR5EEDKCNH2NR4A2HRH1 | |
| SCHEMBL9629452 | 0.81 | SSTR5 (0.91) | SSTR5EEDKCNH2NR4A2HRH1 | |
| SCHEMBL10428776 | 0.81 | KCNH2 (0.76) | SSTR5EEDKCNH2NR4A2HRH1 | |
| SCHEMBL10428777 | 0.81 | SSTR5 (0.66) | SSTR5EEDKCNH2NR4A2HRH1 | |
| SCHEMBL9629256 | 0.81 | KCNH2 (0.46) | SSTR5EEDKCNH2NR4A2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |
| EP-0297661-A1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-04 | — | — | EP | disclosed |