Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | FABP2 | P12104 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424063 | 0.86 | PTGDR2 (0.35) | PTGDR2MTNR1AMTNR1BKMT2ABACE1 | |
| SCHEMBL9630988 | 0.76 | CYP1A2 (0.40) | KMT2APTGS1AKR1C3AKR1C2MEN1 | |
| SCHEMBL9630817 | 0.74 | PTGS1 (0.45) | KMT2APTGS1AKR1C3AKR1C2MEN1 | |
| SCHEMBL9630035 | 0.73 | AKR1C3 (0.57) | KMT2APTGS1AKR1C3AKR1C2MEN1 | |
| SCHEMBL10424064 | 0.71 | AGBL2 (0.47) | LMNACYP2C9HPGDCYP2C19SMN1; SMN2 | |
| SCHEMBL9265039 | 0.71 | KMT2A (0.51) | PTGDR2KMT2APTGS1MEN1LMNA | |
| SCHEMBL7030013 | 0.69 | SMN1; SMN2 (0.50) | KMT2APTGS1MEN1LMNAMAPT | |
| SCHEMBL9892653 | 0.64 | PSEN1 (0.56) | PTGDR2BACE1PTGS1PSEN1PSEN2 | |
| SCHEMBL9631104 | 0.64 | HPGD (0.38) | MTNR1AMTNR1BKMT2AMEN1MAPT | |
| SCHEMBL28771242 | 0.63 | AKR1C3 (0.47) | MTNR1AMTNR1BBACE1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309626-B1 | PROCESS FOR THE PREPARATION OF DIBENZOTHIEPIN DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1992-05-06 | — | — | EP | disclosed |
| US-4891433-A | Process for the preparation of dibenzothiepin derivative | NIPPON CHEMIPHAR CO., LTD. (JP) | 1990-01-02 | — | — | US | disclosed |
| EP-0309626-A1 | Process for the preparation of dibenzothiepin derivative | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |