Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HLA-A | P04439 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10554167 | 0.95 | SSTR5 (0.49) | EEDSSTR5KCNH2NR4A2HTR1A | |
| SCHEMBL9629371 | 0.90 | HTR1A (0.42) | EEDSSTR5KCNH2NR4A2HTR1A | |
| Fumaric Acid SCHEMBL11124984 | 0.88 | SSTR5 (0.45) | EEDSSTR5KCNH2NR4A2HTR1A | |
| SCHEMBL9630454 | 0.87 | EED (0.50) | EEDSSTR5KCNH2NR4A2HTR1A | |
| SCHEMBL9629505 | 0.86 | SSTR5 (0.47) | EEDSSTR5KCNH2NR4A2HTR1A | |
| SCHEMBL9629231 | 0.85 | EED (0.47) | EEDSSTR5KCNH2NR4A2HTR1A | |
| SCHEMBL9688923 | 0.85 | EED (0.46) | EEDSSTR5KCNH2NR4A2HTR1A | |
| Fumaric Acid SCHEMBL9807334 | 0.84 | HTR1A (0.37) | EEDSSTR5KCNH2HTR1ALMNA | |
| SCHEMBL10505664 | 0.83 | SSTR5 (0.46) | EEDSSTR5KCNH2NR4A2HTR1A | |
| SCHEMBL9629611 | 0.83 | EED (0.68) | EEDSSTR5KCNH2NR4A2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |