SCHEMBL9631377

SCHEMBL9631377

CC(C)(C)c1ccc(C(=O)CO)cc1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 4/20 0.47
HSP90AB1 P08238 4/20 0.47
MEN1 O00255 1/20 0.44
POLB P06746 1/20 0.44
APEX1 P27695 1/20 0.44
KMT2A Q03164 1/20 0.44
CTDSP1 Q9GZU7 1/20 0.44
ALDH1A1 P00352 3/20 0.43
MAPT P10636 2/20 0.43
ALOX15 P16050 2/20 0.43
KDM4E B2RXH2 1/20 0.43
CYP1A2 P05177 1/20 0.43
ATP2A2 P16615 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ATP2A3 Q93084 1/20 0.43
SIRT1 Q96EB6 1/20 0.41
LMNA P02545 2/20 0.40
RECQL P46063 1/20 0.40
ESRRA P11474 1/20 0.40
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2582866 0.79 POLB (0.59) HSP90AA1HSP90AB1MEN1POLBAPEX1
SCHEMBL1853155 0.79 ESRRA (0.54) HSP90AA1HSP90AB1MEN1POLBAPEX1
SCHEMBL18618101 0.78 LCK (0.48) HSP90AA1HSP90AB1MEN1POLBAPEX1
SCHEMBL31509307 0.77 CA12 (0.58) MEN1POLBKMT2AMAPTKDM4E
SCHEMBL105705 0.77 CA12 (0.58) MEN1POLBKMT2AMAPTKDM4E
SCHEMBL11002194 0.76 ALDH1A1 (0.41) HSP90AA1HSP90AB1MEN1POLBAPEX1
SCHEMBL9630765 0.76 KDM4E (0.45) HSP90AA1HSP90AB1ALDH1A1KDM4ETSHR
SCHEMBL10622910 0.76 CYP1A2 (0.44) MEN1POLBKMT2AALDH1A1MAPT
SCHEMBL3372362 0.75 CA1 (0.65) MEN1POLBKMT2AALDH1A1MAPT
SCHEMBL12261639 0.75 HSP90AA1 (0.55) HSP90AA1HSP90AB1MEN1POLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5104888-A Anticholesterol or antidiabetic agents SANKYO COMPANY, LIMITED (JP) 1992-04-14 US disclosed
EP-0207581-B1 THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE SANKYO COMPANY LIMITED (JP) 1990-09-12 EP disclosed
EP-0139421-B1 THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM SANKYO COMPANY LIMITED (JP) 1988-04-27 EP disclosed
EP-0076492-B1 HEAT-DEVELOPABLE COLOR PHOTOGRAPHIC MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1987-09-23 EP disclosed
EP-0207581-A2 Thiazolidine derivatives, their preparation and use SANKYO COMPANY LIMITED (JP) 1987-01-07 EP disclosed
US-4572912-A Thiazolidine derivatives, their preparation and compositions containing them SANKYO COMPANY LIMITED (JP) 1986-02-25 US disclosed
US-4555470-A CONTROLLING THE DYE-RELEASING REDOX COMPOUND-SILVER HALIDE REACTION USING A CARBO ESTER; ANTIFOGGING AGENTS; STORAGE STABILITY; THERMOGRAPHY FUJI PHOTO FILM CO., LTD. (JP) 1985-11-26 US disclosed
US-4500626-A DYE RELEASING COMPOUND WHICH REDUCES SILVER HALIDE AND RELEASES HYDROPHILIC DYE FUJI PHOTO FILM CO., LTD. (JP) 1985-02-19 US disclosed
EP-0076492-A2 Heat-developable color photographic material FUJI PHOTO FILM CO., LTD. (JP) 1983-04-13 EP disclosed