Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631414 | 0.79 | PSEN1 (0.53) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9632542 | 0.76 | PSEN1 (0.45) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL13084723 | 0.76 | PSEN1 (0.52) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL4867433 | 0.74 | PSEN1 (0.48) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL3424648 | 0.73 | PSEN1 (0.59) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL13084640 | 0.72 | PSEN1 (0.55) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9075833 | 0.71 | PSEN1 (0.48) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL20024670 | 0.71 | PSEN1 (0.63) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL12064998 | 0.71 | PSEN1 (0.66) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL14544421 | 0.70 | PSEN1 (0.50) | PSEN1MEN1KMT2APDE4APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104888-A | Anticholesterol or antidiabetic agents | SANKYO COMPANY, LIMITED (JP) | 1992-04-14 | — | — | US | disclosed |
| EP-0207581-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE | SANKYO COMPANY LIMITED (JP) | 1990-09-12 | — | — | EP | disclosed |
| EP-0207581-A2 | Thiazolidine derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |