Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GSTO1 | P78417 | 6/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398067 | 0.81 | ATP4A (0.42) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL8974700 | 0.80 | ROCK1 (0.47) | MAPTALDH1A1SMN1; SMN2HTTHSD17B10 | |
| Hydrochloric Acid SCHEMBL10340397 | 0.80 | ATP4A (0.41) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL10590650 | 0.80 | ATP4A (0.44) | MAPTALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL9788069 | 0.80 | MEN1 (0.36) | MAPTALDH1A1SMN1; SMN2HTTRAB9A | |
| Hydrochloric Acid SCHEMBL10591848 | 0.79 | ATP4A (0.43) | MAPTALDH1A1RAB9ANPC1MEN1 | |
| Hydrochloric Acid SCHEMBL10454848 | 0.79 | ROCK1 (0.46) | MAPTALDH1A1SMN1; SMN2HTTHSD17B10 | |
| Hydrochloric Acid SCHEMBL9366035 | 0.79 | ATP4A (0.41) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL10591610 | 0.78 | MEN1 (0.44) | MAPTALDH1A1SMN1; SMN2HTTHSD17B10 | |
| Zaltidine SCHEMBL3605309 | 0.77 | ATP4A (0.39) | ALDH1A1HSD17B10RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357192-B1 | PROCESS FOR PREPARING SUBSTITUTED GUANYLTHIOUREAS | PFIZER INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0357192-A1 | Process for preparing substituted guanylthioureas | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |