Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | DAO | P14920 | 1/20 | 0.59 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454538 | 0.89 | DRD2 (0.62) | IDO1FLT3KDM4EHPGDMAPT | |
| SCHEMBL30148093 | 0.86 | IDO1 (0.66) | IDO1FLT3KDM4EHPGDMAPT | |
| SCHEMBL2730199 | 0.86 | IDO1 (0.66) | IDO1FLT3KDM4EHPGDMAPT | |
| SCHEMBL9100296 | 0.85 | IDO1 (0.64) | IDO1FLT3KDM4EHPGDMAPT | |
| SCHEMBL28038704 | 0.84 | IDO1 (0.59) | IDO1FLT3KDM4EHPGDMAPT | |
| Indole-2-Carboxylic Acid SCHEMBL30748205 | 0.83 | KDM4E (0.73) | IDO1FLT3KDM4EHPGDMAPT | |
| Acetic Acid SCHEMBL11542600 | 0.82 | IDO1 (0.65) | IDO1FLT3KDM4EHPGDMAPT | |
| Butyric Acid SCHEMBL28840260 | 0.81 | KDM4E (0.57) | IDO1FLT3KDM4EHPGDMAPT | |
| SCHEMBL6923977 | 0.81 | IDO1 (0.68) | IDO1FLT3KDM4EHPGDMAPT | |
| SCHEMBL9666519 | 0.80 | IDO1 (0.62) | IDO1FLT3KDM4EHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377981-B2 | CBI derivatives subject to reductive activation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-19 | — | — | US | disclosed |
| US-5089497-A | Dopaminergic agents | WARNER-LAMBERT COMPANY (US) | 1992-02-18 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | disclosed |