SCHEMBL963365

SCHEMBL963365

CCCNc1ccccc1C(=O)NN

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.49
KDM4E B2RXH2 2/20 0.49
GLA P06280 1/20 0.49
CTSD P07339 2/20 0.49
CNR2 P34972 3/20 0.48
ADRA1D P25100 2/20 0.48
ADRA1A P35348 2/20 0.48
ADRA1B P35368 2/20 0.48
ALDH1A1 P00352 4/20 0.47
HPGD P15428 2/20 0.47
HSD17B10 Q99714 2/20 0.47
GAA P10253 1/20 0.47
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45
IDO1 P14902 1/20 0.44
P2RX7 Q99572 1/20 0.44
KDM6B O15054 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL960584 0.86 CTSD (0.51) L3MBTL1KDM4EGLACTSDADRA1D
SCHEMBL5392212 0.84 KDM4E (0.58) KDM4EGLAADRA1DADRA1AADRA1B
SCHEMBL23340114 0.83 HDAC1 (0.51) L3MBTL1KDM4EALDH1A1HSD17B10GAA
SCHEMBL1902821 0.82 HPGD (0.69) L3MBTL1KDM4EGLAALDH1A1HPGD
SCHEMBL14470975 0.82 KDM4E (0.51) L3MBTL1KDM4EGLACNR2ADRA1D
SCHEMBL20274413 0.81 KDM4E (0.50) L3MBTL1KDM4EGLACNR2ADRA1D
SCHEMBL2493412 0.80 IDO1 (0.50) L3MBTL1KDM4EGLACNR2ADRA1D
SCHEMBL7819029 0.79 KDM4E (0.76) KDM4EGLAADRA1DADRA1AADRA1B
SCHEMBL960781 0.78 KDM4E (0.58) KDM4ECTSDADRA1DADRA1AADRA1B
SCHEMBL8585150 0.78 KMT2A (0.59) KDM4EGLAALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2248833-B1 MODIFIED DIENE RUBBER, METHOD FOR PRODUCING THE SAME, RUBBER COMPOSITION USING THE SAME, AND TIRE BRIDGESTONE CORP (JP) 2014-03-26 EP disclosed
US-20130289165-A1 COMPOSITION BASED ON NATURAL RUBBER AND CARBON BLACK COMPRISING A HYDRAZIDE, A HYDRAZONE AND A POLYAMINE MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2013-10-31 US disclosed
US-8389641-B2 Modified diene rubber, production method thereof, and rubber composition and tire using the rubber BRIDGESTONE CORPORATION (JP) 2013-03-05 US disclosed
US-20110003911-A1 MODIFIED DIENE RUBBER, PRODUCTION METHOD THEREOF, AND RUBBER COMPOSITION AND TIRE USING THE RUBBER BRIDGESTONE CORPORATION (JP) 2011-01-06 US disclosed
EP-2248833-A1 MODIFIED DIENE RUBBER, METHOD FOR PRODUCING THE SAME, RUBBER COMPOSITION USING THE SAME, AND TIRE Bridgestone Corporation (JP) 2010-11-10 EP disclosed
US-20100249336-A1 MODIFIED NATURAL RUBBER AND METHOD FOR PRODUCING SAME, AND RUBBER COMPOSITION AND TIRE USING SUCH A MODIFIED NATURAL RUBBER BRIDGESTONE CORPORATION (JP) 2010-09-30 US disclosed
EP-2206730-A1 MODIFIED NATURAL RUBBER, PROCESS FOR PRODUCTION OF THE SAME, AND RUBBER COMPOSITION AND TIRE EACH COMPRISING THE SAME Bridgestone Corporation (JP) 2010-07-14 EP disclosed