Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23746417 | 0.80 | HIF1A (0.52) | HIF1APTPN1MGAMGAASI | |
| SCHEMBL10431871 | 0.76 | HIF1A (0.49) | HIF1APTPN1MGAMGAASI | |
| SCHEMBL8616456 | 0.76 | KDM4E (0.48) | PTPN1MGAMGAASIACHE | |
| SCHEMBL8370012 | 0.75 | MGAM (0.47) | HIF1APTPN1MGAMGAASI | |
| SCHEMBL3310654 | 0.75 | MGAM (0.47) | HIF1APTPN1MGAMGAASI | |
| SCHEMBL9634323 | 0.75 | HIF1A (0.49) | HIF1APTPN1MGAMGAASI | |
| SCHEMBL14327003 | 0.74 | PTPN1 (0.47) | HIF1APTPN1MGAMGAASI | |
| SCHEMBL9634302 | 0.73 | HIF1A (0.52) | HIF1APTPN1MGAMGAASI | |
| SCHEMBL11000607 | 0.72 | KCNE1 (0.37) | HIF1AALDH1A1KDM4EMAPK1 | |
| SCHEMBL13094065 | 0.72 | PTPN1 (0.51) | HIF1APTPN1MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112972-A | Cardiovascular disorders as hypotensive agents, angina pectoris | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |