Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.82 |
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.82 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.82 |
| ▸ | SQLE | Q14534 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | EBP | Q15125 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633991 | 1.00 | CYP2D6 (0.82) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL36794 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL2042785 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL29627458 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL31374681 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL2028187 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL37843 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL5279646 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL29353314 | 0.90 | CYP2D6 (1.00) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A | |
| Terbinafine SCHEMBL14060971 | 0.89 | CYP2D6 (0.93) | CYP2D6LMNASLC6A2SIGMAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132459-A | Fungicides | SANDOZ LTD. (CH) | 1992-07-21 | — | — | US | disclosed |
| US-4755534-A | Propenylamines, pharmaceutical compositions containing them and their use as pharmaceuticals | SANDOZ LTD. (CH) | 1988-07-05 | — | — | US | disclosed |
| EP-0024587-A1 | Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals | SANDOZ AG (CH) | 1981-03-11 | — | — | EP | disclosed |