Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.65 |
| ▸ | AURKA | O14965 | 3/20 | 0.65 |
| ▸ | PDE4A | P27815 | 9/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635687 | 0.91 | PDE5A (0.61) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9636334 | 0.90 | PDE5A (0.67) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9635949 | 0.88 | PDE5A (0.64) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9634875 | 0.84 | PDE5A (0.57) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9635759 | 0.83 | PDE5A (0.70) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9636135 | 0.83 | AURKA (0.54) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9634270 | 0.81 | PDE2A (0.61) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9635780 | 0.81 | PDE2A (0.75) | PDE5AAURKAPDE4APDE4BPDE4C | |
| SCHEMBL9634658 | 0.81 | PDE5A (0.52) | PDE5AAURKAKDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10906179 | 0.81 | PDE2A (0.73) | PDE5AAURKAPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |