Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.57 |
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10908413 | 0.91 | PDE5A (0.61) | PDE5AAURKAPDE2APDE4APDE4B | |
| SCHEMBL11768369 | 0.88 | PDE5A (0.72) | PDE5AAURKAPDE2APDE4APDE4B | |
| SCHEMBL10741211 | 0.85 | METAP2 (0.40) | PDE5AAURKAPDE2AALDH1A1HPGD | |
| SCHEMBL9635687 | 0.84 | PDE5A (0.61) | PDE5AAURKAPDE2APDE4APDE4B | |
| SCHEMBL9634337 | 0.84 | PDE5A (0.65) | PDE5AAURKAPDE2APDE4APDE4B | |
| SCHEMBL9635680 | 0.82 | AURKA (0.56) | PDE5AAURKAPDE2AALDH1A1HPGD | |
| SCHEMBL9635658 | 0.82 | AURKA (0.56) | PDE5AAURKAPDE2AALDH1A1HPGD | |
| SCHEMBL9635759 | 0.81 | PDE5A (0.70) | PDE5AAURKAPDE2APDE4APDE4B | |
| SCHEMBL9636135 | 0.81 | AURKA (0.54) | PDE5AAURKAPDE2APDE4APDE4B | |
| SCHEMBL9635975 | 0.80 | PDE5A (0.46) | PDE5AAURKAALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |