Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9838295 | 0.99 | PDE5A (0.41) | PDE5AKDM4EALDH1A1HPGDAURKA | |
| SCHEMBL9635718 | 0.86 | KDM4C (0.38) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL9634651 | 0.84 | METAP1 (0.39) | PDE5AKDM4EALDH1A1HPGDAURKA | |
| SCHEMBL10917045 | 0.83 | AMY1A (0.33) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL9636130 | 0.83 | METAP1 (0.34) | PDE5AKDM4EALDH1A1AURKAKDR | |
| SCHEMBL9634494 | 0.83 | PDE10A (0.35) | PDE5AKDM4EALDH1A1METAP1PKN1 | |
| SCHEMBL9636107 | 0.82 | PDE5A (0.36) | PDE5AKDM4EALDH1A1HPGDAURKA | |
| Hydrochloric Acid SCHEMBL10743666 | 0.82 | AMY1A (0.33) | PDE5AKDM4EALDH1A1HPGDMETAP1 | |
| SCHEMBL9636047 | 0.82 | FGFR1 (0.40) | PDE5AKDM4EALDH1A1HPGDAURKA | |
| Hydrochloric Acid SCHEMBL10847863 | 0.81 | FGFR1 (0.39) | PDE5AKDM4EALDH1A1HPGDAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | claimed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | claimed |
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| US-4603139-A | 2-PHENYL-1H-IMIDAZOL(4,5-C)PYRIDINES, ANTICXOAGULANTS, CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. | 1986-07-29 | — | — | US | disclosed |
| EP-0079083-A1 | New imidazo[4,5-c]pyridine derivatives, processes for their preparation and pharmaceutical formulations containing such compounds | MERCK PATENT GmbH (DE) | 1983-05-18 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |