Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 13/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635443 | 0.88 | PDE5A (0.53) | PDE5APDE10AKDM4EALDH1A1TP53 | |
| SCHEMBL10742508 | 0.85 | PDE5A (0.46) | PDE5APDE10AKDM4EALDH1A1TP53 | |
| SCHEMBL9634527 | 0.85 | PDE5A (0.39) | PDE5APDE10AKDM4EALDH1A1TP53 | |
| SCHEMBL9635621 | 0.84 | CDK4 (0.40) | PDE5APDE10AKDM4EALDH1A1TP53 | |
| SCHEMBL9635639 | 0.84 | PDE5A (0.62) | PDE5APDE10AKDM4EALDH1A1PDE4A | |
| SCHEMBL9636160 | 0.82 | PDE2A (0.47) | PDE5APDE10AKDM4EALDH1A1NPC1 | |
| SCHEMBL9635706 | 0.81 | PDE5A (0.63) | PDE5APDE10APDE4APDE4BPDE4C | |
| SCHEMBL9635857 | 0.81 | PDE5A (0.71) | PDE5APDE10AKDM4EALDH1A1PDE4A | |
| SCHEMBL9634482 | 0.81 | PDE5A (0.38) | PDE5APDE10AKDM4EALDH1A1TP53 | |
| SCHEMBL9636094 | 0.81 | CBFB (0.41) | PDE5APDE10AKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |