Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 7/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635857 | 0.88 | PDE5A (0.71) | PDE5APDE10APDE4APDE4BPDE4C | |
| SCHEMBL7271001 | 0.86 | PDE5A (0.61) | PDE5APDE10APDE4APDE4BPDE4C | |
| SCHEMBL10416662 | 0.85 | PDE5A (0.57) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635639 | 0.85 | PDE5A (0.62) | PDE5APDE10APDE4APDE4BPDE4C | |
| SCHEMBL9634947 | 0.84 | PDE5A (0.46) | PDE5APDE10A | |
| SCHEMBL9636138 | 0.84 | PDE5A (0.46) | PDE5A | |
| SCHEMBL9634571 | 0.83 | MEN1 (0.59) | PDE5APDE10APDE4APDE4BPDE4C | |
| SCHEMBL7279141 | 0.82 | PDE5A (0.57) | PDE5APDE10APDE4APDE4BPDE4C | |
| SCHEMBL9635705 | 0.82 | PDE2A (0.47) | PDE5A | |
| SCHEMBL9634602 | 0.81 | PDE5A (0.53) | PDE5APDE10APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |