Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636233 | 0.90 | PDE2A (0.61) | PDE5APDE2AFAAHPDE4APDE4B | |
| SCHEMBL9634845 | 0.88 | PDE2A (0.56) | PDE5APDE2AFAAHPDE4APDE4B | |
| SCHEMBL9635758 | 0.87 | PDE2A (0.73) | PDE5APDE2AFAAHPDE4APDE4B | |
| SCHEMBL9635750 | 0.86 | PDE5A (0.61) | PDE5APDE2AFAAHPDE4APDE4B | |
| SCHEMBL9635647 | 0.86 | ADORA2A (0.55) | PDE5APDE2AFAAHPRMT5PDE4A | |
| SCHEMBL14090341 | 0.85 | PRMT5 (0.70) | PDE5APDE2APRMT5PDE4APDE4B | |
| SCHEMBL9634549 | 0.83 | PDE2A (0.53) | PDE5APDE2AFAAHPDE4APDE4B | |
| SCHEMBL9635767 | 0.83 | PDE2A (0.53) | PDE5APDE2AFAAHPDE4APDE4B | |
| SCHEMBL9635691 | 0.83 | PRMT5 (0.67) | FAAHPRMT5 | |
| SCHEMBL9635708 | 0.82 | AURKA (0.66) | FAAHPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |