Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.66 |
| ▸ | FAAH | O00519 | 2/20 | 0.63 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635808 | 0.87 | AURKA (0.69) | AURKAFAAHPRMT5HPSEKDM4E | |
| SCHEMBL9635691 | 0.86 | PRMT5 (0.67) | AURKAFAAHPRMT5HPSEMEN1 | |
| SCHEMBL9634633 | 0.85 | AURKA (0.63) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9634703 | 0.82 | PDE5A (0.57) | FAAHPRMT5 | |
| SCHEMBL9636233 | 0.81 | PDE2A (0.61) | AURKAFAAHKDM4EMEN1ALDH1A1 | |
| SCHEMBL9635915 | 0.80 | AURKA (0.67) | AURKAFAAHPRMT5 | |
| SCHEMBL9634626 | 0.80 | AURKA (0.67) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9635899 | 0.79 | MEN1 (0.53) | FABP4KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL9635758 | 0.79 | PDE2A (0.73) | AURKAFAAHKDM4EMEN1ALDH1A1 | |
| SCHEMBL14027835 | 0.79 | KDM4E (0.65) | AURKAFAAHPRMT5HPSEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |