Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634469 | 0.96 | PDE5A (0.41) | PDE5ACHEK2GCGRMAPK13MAPK12 | |
| SCHEMBL9635742 | 0.92 | PDE5A (0.39) | PDE5AGCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL9636138 | 0.91 | PDE5A (0.46) | PDE5ACHEK2GCGRMAPK13MAPK12 | |
| SCHEMBL9634764 | 0.88 | CBFB (0.41) | PDE5AGCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL9634828 | 0.87 | PDE5A (0.45) | PDE5ACHEK2GCGRMAPK13MAPK12 | |
| SCHEMBL7277622 | 0.87 | PDE2A (0.47) | PDE5APDE3BPDE3ALMNASMN1; SMN2 | |
| SCHEMBL9636296 | 0.86 | PDE3B (0.39) | PDE5APDE3BPDE3AP2RY12LMNA | |
| SCHEMBL9635794 | 0.86 | PDE5A (0.40) | PDE5AGCGRMAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL10848480 | 0.86 | PDE2A (0.46) | PDE5APDE3BPDE3ALMNASMN1; SMN2 | |
| SCHEMBL9634601 | 0.85 | TOP1 (0.36) | PDE5AGCGRMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |