Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 4/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634529 | 0.91 | PDE3B (0.43) | PDE3BPDE3APDE2AP2RY12LMNA | |
| SCHEMBL9635742 | 0.90 | PDE5A (0.39) | PDE3BPDE3APDE2ALMNASMN1; SMN2 | |
| SCHEMBL9635747 | 0.90 | LMNA (0.42) | PDE3BPDE3APDE2AP2RY12LMNA | |
| SCHEMBL9636187 | 0.88 | PDE3B (0.43) | PDE3BPDE3AP2RY12LMNASMN1; SMN2 | |
| SCHEMBL9634389 | 0.87 | MAPT (0.45) | PDE3BPDE3APDE2AP2RY12LMNA | |
| SCHEMBL9634904 | 0.86 | PDE5A (0.39) | PDE3BPDE3APDE2AP2RY12LMNA | |
| SCHEMBL9634292 | 0.86 | PDE5A (0.49) | PDE3BPDE3APDE2AP2RY12LMNA | |
| SCHEMBL9634764 | 0.86 | CBFB (0.41) | PDE3BPDE3APDE2ALMNASMN1; SMN2 | |
| SCHEMBL7277622 | 0.85 | PDE2A (0.47) | PDE3BPDE3APDE2ALMNASMN1; SMN2 | |
| SCHEMBL9635773 | 0.85 | PDE3B (0.39) | PDE3BPDE3APDE2AP2RY12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |