Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966841 | 0.92 | CCNC (0.38) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL962379 | 0.91 | PIM3 (0.39) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL963486 | 0.90 | MCL1 (0.37) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL961608 | 0.89 | MCL1 (0.38) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL966599 | 0.89 | ABL1 (0.37) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL967493 | 0.88 | CA12 (0.42) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL964594 | 0.88 | CCNC (0.35) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL966849 | 0.88 | TDP1 (0.36) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL966848 | 0.88 | TDP1 (0.36) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL966513 | 0.88 | ALDH1A1 (0.44) | MTNR1AMTNR1BMAPTCA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009384-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | PPARA, PPARD, PPARG | CYP1A2 665/4885CYP3A4 474/4885CYP2D6 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.