Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227336 | 0.89 | NPSR1 (0.40) | NPSR1GAAMEN1KMT2ACYP2D6 | |
| SCHEMBL11232137 | 0.87 | CYP24A1 (0.40) | NPSR1GAAMEN1KMT2ACYP2D6 | |
| SCHEMBL2349218 | 0.83 | CYP2D6 (0.43) | GAAMEN1KMT2AF2CYP2D6 | |
| SCHEMBL6926829 | 0.83 | CHRM3 (0.38) | CYP2D6MAPK1ALDH1A1 | |
| SCHEMBL5744395 | 0.82 | CYP2D6 (0.57) | NPSR1GAAMEN1KMT2ACYP2D6 | |
| SCHEMBL14166152 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL13922213 | 0.79 | CYP2D6 (0.58) | KMT2AF2CYP2D6CYP1A2KDM4E | |
| SCHEMBL16797311 | 0.79 | CYP2D6 (0.44) | GAAMEN1KMT2ACYP2D6CYP1A2 | |
| SCHEMBL8433286 | 0.78 | MEN1 (0.37) | NPSR1GAAMEN1KMT2ACYP2D6 | |
| SCHEMBL9786828 | 0.78 | MEN1 (0.37) | NPSR1GAAMEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114949-A | Treating disorders associated with 5HT uptake | RHONE-POULENC SANTE (FR) | 1992-05-19 | — | — | US | disclosed |
| US-4357337-A | PIPERIDINYLALKYL DERIVATIVES | PHARMINDUSTRIE (FR) | 1982-11-02 | — | — | US | disclosed |