Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633718 | 0.92 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19NR1H4EPHX2 | |
| SCHEMBL9635012 | 0.70 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL1542356 | 0.68 | MEN1 (0.61) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL6422179 | 0.67 | CYP1A2 (0.73) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL20468259 | 0.67 | MAPT (0.51) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL4440336 | 0.66 | CYP1A2 (1.00) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL16839623 | 0.66 | MAPT (0.57) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL184552 | 0.66 | MAPT (0.57) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL8429886 | 0.66 | MAPT (0.60) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL2252810 | 0.64 | MAPT (0.58) | CYP1A2CYP2C9CYP2C19MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |