Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634205 | 0.83 | CYSLTR2 (0.53) | CYP1A2CYP2C19MEN1KMT2ACYSLTR2 | |
| SCHEMBL9647175 | 0.81 | MAPT (0.44) | NQO2MTNR1AMTNR1BMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL9635452 | 0.80 | MAPT (0.43) | NQO2MTNR1AMTNR1BMAPTMEN1 | |
| SCHEMBL9635034 | 0.75 | CYSLTR2 (0.62) | MEN1KMT2ACYSLTR2CYSLTR1 | |
| SCHEMBL9634711 | 0.73 | NQO2 (0.41) | CYP1A2CYP2C9CYP2C19NQO2MTNR1A | |
| SCHEMBL9634219 | 0.73 | MEN1 (0.35) | NQO2MTNR1AMTNR1BMAPTMEN1 | |
| SCHEMBL9635481 | 0.70 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL9634778 | 0.68 | NQO2 (0.40) | CYP1A2CYP2C9CYP2C19NQO2MTNR1A | |
| SCHEMBL1542356 | 0.68 | MEN1 (0.61) | CYP1A2CYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL6422179 | 0.66 | CYP1A2 (0.73) | CYP1A2CYP2C9CYP2C19NPY5RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |