Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.72 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29495358 | 0.89 | AKR1B1 (0.80) | MAOBAKR1B1ALOX15MAOAKMT2A | |
| SCHEMBL115442 | 0.89 | AKR1B1 (0.80) | MAOBAKR1B1ALOX15MAOAKMT2A | |
| SCHEMBL4258065 | 0.87 | MAOB (0.72) | MAOBAKR1B1ATMKMT2AALDH1A1 | |
| SCHEMBL4251638 | 0.82 | MAOB (0.65) | MAOBAKR1B1MAOAATMKMT2A | |
| SCHEMBL2814301 | 0.80 | AKR1B1 (0.69) | MAOBAKR1B1ALOX15KMT2AALDH1A1 | |
| SCHEMBL4258027 | 0.80 | MAOB (0.62) | MAOBAKR1B1ATMKMT2AALDH1A1 | |
| SCHEMBL4249673 | 0.79 | MAOB (0.72) | MAOBAKR1B1ATMKMT2AALDH1A1 | |
| SCHEMBL4254462 | 0.79 | MAOB (0.60) | MAOBAKR1B1ALOX15KMT2AALDH1A1 | |
| SCHEMBL29495537 | 0.78 | AKR1B1 (1.00) | MAOBAKR1B1ALOX15MAOAATM | |
| SCHEMBL1021783 | 0.78 | AKR1B1 (1.00) | MAOBAKR1B1ALOX15MAOAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082849-A | Antiinflammatory agents or antiallergens | AVENTIS PHARMACEUTICALS INC. | 1992-01-21 | — | — | US | disclosed |
| EP-0434827-A4 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1992-01-08 | — | — | EP | disclosed |
| EP-0434827-A1 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991001123-A2 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4977162-A | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments | RORER PHARMACEUTICAL CORPORATION (US) | 1990-12-11 | — | — | US | disclosed |