Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 5/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634777 | 0.88 | PDE5A (0.57) | PDE5APDE2APDE4APDE4BPDE4C | |
| SCHEMBL9634394 | 0.88 | PDE2A (0.62) | PDE5APDE2APDE4APDE4BPDE4C | |
| SCHEMBL9635780 | 0.85 | PDE2A (0.75) | PDE5APDE2APDE4APDE4BPDE4C | |
| SCHEMBL9634620 | 0.85 | PDE5A (0.52) | PDE5APDE2APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL10906179 | 0.84 | PDE2A (0.73) | PDE5APDE2APDE4APDE4BPDE4C | |
| SCHEMBL9634842 | 0.84 | PDE5A (0.63) | PDE5APDE2APDE4APDE4BPDE4C | |
| SCHEMBL9634862 | 0.84 | PDE2A (0.56) | PDE5APDE2APDE4APDE4BPDE4C | |
| SCHEMBL9635720 | 0.84 | PDE2A (0.56) | PDE5APDE2APDE4APDE4BPDE4C | |
| SCHEMBL10742154 | 0.83 | METAP2 (0.38) | PDE5APDE2AMGAMGAASI | |
| SCHEMBL9634782 | 0.83 | PDE2A (0.53) | PDE5APDE2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |